Cross-Reactive Neutralizing Antibodies Directed against Pandemic H1N1 2009 Virus Are Protective in a Highly Sensitive DBA/2 Mouse Influenza Model

Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The maj...

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Detalles Bibliográficos
Main Authors: Boon, Adrianus C. M., deBeauchamp, Jennifer, Krauss, Scott, Rubrum, Adam, Webb, Ashley D., Webster, Robert G., McElhaney, Janet, Webby, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897626/
https://ncbi.nlm.nih.gov/pubmed/20484500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02444-09
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