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Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

The mechanisms underlying the AIDS resistance of natural hosts for simian immunodeficiency virus (SIV) remain unknown. Recently, it was proposed that natural SIV hosts avoid disease because their plasmacytoid dendritic cells (pDCs) are intrinsically unable to produce alpha interferon (IFN-α) in resp...

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書誌詳細
主要な著者: Harris, Levelle D., Tabb, Brian, Sodora, Donald L., Paiardini, Mirko, Klatt, Nichole R., Douek, Daniel C., Silvestri, Guido, Müller-Trutwin, Michaela, Vasile-Pandrea, Ivona, Apetrei, Cristian, Hirsch, Vanessa, Lifson, Jeffrey, Brenchley, Jason M., Estes, Jacob D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897601/
https://ncbi.nlm.nih.gov/pubmed/20484518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02612-09
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