Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

The mechanisms underlying the AIDS resistance of natural hosts for simian immunodeficiency virus (SIV) remain unknown. Recently, it was proposed that natural SIV hosts avoid disease because their plasmacytoid dendritic cells (pDCs) are intrinsically unable to produce alpha interferon (IFN-α) in resp...

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Autori principali: Harris, Levelle D., Tabb, Brian, Sodora, Donald L., Paiardini, Mirko, Klatt, Nichole R., Douek, Daniel C., Silvestri, Guido, Müller-Trutwin, Michaela, Vasile-Pandrea, Ivona, Apetrei, Cristian, Hirsch, Vanessa, Lifson, Jeffrey, Brenchley, Jason M., Estes, Jacob D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897601/
https://ncbi.nlm.nih.gov/pubmed/20484518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02612-09
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