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Copper-Mediated N-Alkynylation of Carbamates, Ureas, and Sulfonamides. A General Method for the Synthesis of Ynamides

[Image: see text] A general amination strategy for the N-alkynylation of carbamates, sulfonamides, and chiral oxazolidinones and imidazolidinones is described. A variety of substituted ynamides are available by deprotonation of amides with KHMDS followed by reaction with CuI and an alkynyl bromide.

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Detalhes bibliográficos
Main Authors: Dunetz, Joshua R., Danheiser, Rick L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897059/
https://ncbi.nlm.nih.gov/pubmed/14535766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol035647d
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