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Ribosomal Protein S7 is both a Regulator and Substrate of MDM2
MDM2 associates with ribosomal protein S7 and this interaction is required to inhibit MDM2’s E3 ligase activity leading to stabilization of MDM2 and p53. Notably, the MDM2 homologue MDMX facilitates the inhibition of MDM2 E3 ligase activity by S7. Further, ablation of S7 inhibits MDM2 and p53 accumu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896961/ https://ncbi.nlm.nih.gov/pubmed/19683495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.07.014 |
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