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Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accessed by a Palladium-Catalyzed Enantioselective Alkene Difunctionalization Reaction
A unique alkene difunctionalization reaction has been developed which allows rapid construction of molecular complexity around the biologically relevant indole framework. The reaction proceeds with up to 87% yield, 99:1 er and >20:1 dr. Evaluation of several of the compounds reveals promising ant...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896870/ https://ncbi.nlm.nih.gov/pubmed/20486685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103472a |
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