The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

The phosphoinositide 3-kinase (PI3K) pathway is a major target for cancer drug development. PI-103 is an isoform-selective class I PI3K and mammalian target of rapamycin inhibitor. The aims of this work were as follows: first, to use magnetic resonance spectroscopy (MRS) to identify and develop a ro...

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Autores principales: Al-Saffar, Nada M. S., Jackson, L. Elizabeth, Raynaud, Florence I., Clarke, Paul A., de Molina, Ana Ramírez, Lacal, Juan C., Workman, Paul, Leach, Martin O.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896552/
https://ncbi.nlm.nih.gov/pubmed/20551061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4476
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