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Determinants of BH3 binding specificity for Mcl-1 vs. Bcl-x(L)
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival members of the family interact with pro-apoptotic BH3-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-h...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896288/ https://ncbi.nlm.nih.gov/pubmed/20363230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.058 |
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