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Mutation of Putative N-linked Glycosylation Sites on the Human Nucleotide Receptor P2X(7) Reveals a Key Residue Important for Receptor Function
The nucleotide receptor P2X(7) is an immunomodulatory cation channel and a potential therapeutic target. P2X(7) is expressed in immune cells such as monocytes/macrophages and is activated by extracellular ATP following tissue injury or infection. Ligand binding to P2X(7) can stimulate ERK1/2, the tr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895974/ https://ncbi.nlm.nih.gov/pubmed/20450227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902083n |
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