Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells

Activation of the ionotropic P2RX7 nucleotide receptor by extracellular ATP has been implicated in modulating inflammatory disease progression. Continuous exposure of P2RX7 to ligand can result in apoptosis in many cell types, including monocytic cells, whereas transient activation of P2RX7 is linke...

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Detalhes bibliográficos
Main Authors: Gavala, Monica L., Hill, Lindsay M., Lenertz, Lisa Y., Karta, Maya R., Bertics, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962527/
https://ncbi.nlm.nih.gov/pubmed/20813842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.142091
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