Doubly Truncated FosB Isoform (Δ2ΔFosB) Induces Osteosclerosis in Transgenic Mice and Modulates Expression and Phosphorylation of Smads in Osteoblasts Independent of Intrinsic AP-1 Activity

INTRODUCTION: Activator protein (AP)-1 family members play important roles in the development and maintenance of the adult skeleton. Transgenic mice that overexpress the naturally occurring ΔFosB splice variant of FosB develop severe osteosclerosis. Translation of Δfosb mRNA produces both ΔFosB and...

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Détails bibliographiques
Auteurs principaux: Sabatakos, George, Rowe, Glenn C, Kveiborg, Marie, Wu, Meilin, Neff, Lynn, Chiusaroli, Riccardo, Philbrick, William M, Baron, Roland
Format: Artigo
Langue:Inglês
Publié: Amer Soc Bone & Mineral Res. 2008
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674536/
https://ncbi.nlm.nih.gov/pubmed/18433296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080110
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