A One-Pot, 3-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1,2-benzisothiazoline-3-acetic acids

A sequential three-component synthesis of functionalized benzisothiazoline-3-acetic acid 1,1-dioxides utilizing a domino Heck-aza-Michael pathway is reported. This one-pot procedure rapidly assembles functionalized benzylsulfonamides, which undergo a palladium-catalyzed, domino, Heck-aza-Michael tra...

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Huvudupphovsmän: Rolfe, Alan, Young, Kyle, Volp, Kelly, Schoenen, Frank, Neuenswander, Benjamin, Lushington, Gerald H., Hanson, Paul R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895961/
https://ncbi.nlm.nih.gov/pubmed/19505109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc900025e
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