Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13

BACKGROUND: Atopic dermatitis (AD) is characterized by local and systemic Th2 responses to cutaneously introduced allergens and is a risk factor for asthma. Blockade of Th2 cytokines has been suggested as therapy for AD. OBJECTIVES: To examine the effect of the absence of IL-4 and IL-13 on the Th-17...

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Hauptverfasser: He, Rui, Kim, Hye Young, Yoon, Juhan, Oyoshi, Michiko, MacGinnitie, Andrew, Goya, Sho, Freyschmidt, Eva-Jasmin, Bryce, Paul, McKenzie, Andrew N.J., Umetsu, Dale T., Oettgen, Hans, Geha, Raif S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895457/
https://ncbi.nlm.nih.gov/pubmed/19815118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.07.040
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