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Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

Primary cilia are present on most mammalian cells and are implicated in transducing Hedgehog (Hh) signals during development; however, the prevalence of cilia on human tumors remains unclear, and the role of cilia in cancer has not been examined. Here we show that human basal cell carcinomas (BCCs)...

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Bibliografski detalji
Glavni autori: Wong, Sunny Y, Seol, Allen D, So, Po-Lin, Ermilov, Alexandre N, Bichakjian, Christopher K, Epstein, Ervin H, Dlugosz, Andrzej A, Reiter, Jeremy F
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895420/
https://ncbi.nlm.nih.gov/pubmed/19701205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2011
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