Inhibitory Effects of Insulin-like Growth Factor-1 and Osteogenic Protein-1 on Fibronectin Fragment- and Interleukin-1β-stimulated Matrix Metalloproteinase-13 Expression in Human Chondrocytes

Matrix metalloproteinase-13 (collagenase-3), a member of the family of matrix metalloproteinases (MMPs), plays a major pathological role in the cartilage destruction of arthritis. A dramatic up-regulation of MMP-13 by inflammatory cytokines such as interleukin (IL)-1β or by fibronectin fragments has...

Full description

Saved in:
Bibliographic Details
Main Authors: Im, Hee-Jeong, Pacione, Carol, Chubinskaya, Susan, van Wijnen, Andre J., Sun, Yubo, Loeser, Richard F.
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895259/
https://ncbi.nlm.nih.gov/pubmed/12734180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M302048200
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items