The Prp19 complex and the Usp4(Sart3) deubiquitinating enzyme control reversible ubiquitination at the spliceosome

The spliceosome, a dynamic assembly of proteins and RNAs, catalyzes the excision of intron sequences from nascent mRNAs. Recent work has suggested that the activity and composition of the spliceosome are regulated by ubiquitination, but the underlying mechanisms have not been elucidated. Here, we re...

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Autores principales: Song, Eun Joo, Werner, Shannon L., Neubauer, Jakob, Stegmeier, Frank, Aspden, Julie, Rio, Donald, Harper, J. Wade, Elledge, Stephen J., Kirschner, Marc W., Rape, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2010
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895201/
https://ncbi.nlm.nih.gov/pubmed/20595234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1925010
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