The Prp19 complex and the Usp4(Sart3) deubiquitinating enzyme control reversible ubiquitination at the spliceosome

The spliceosome, a dynamic assembly of proteins and RNAs, catalyzes the excision of intron sequences from nascent mRNAs. Recent work has suggested that the activity and composition of the spliceosome are regulated by ubiquitination, but the underlying mechanisms have not been elucidated. Here, we re...

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Bibliographische Detailangaben
Hauptverfasser: Song, Eun Joo, Werner, Shannon L., Neubauer, Jakob, Stegmeier, Frank, Aspden, Julie, Rio, Donald, Harper, J. Wade, Elledge, Stephen J., Kirschner, Marc W., Rape, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2010
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895201/
https://ncbi.nlm.nih.gov/pubmed/20595234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1925010
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