The Prp19 complex and the Usp4(Sart3) deubiquitinating enzyme control reversible ubiquitination at the spliceosome

The spliceosome, a dynamic assembly of proteins and RNAs, catalyzes the excision of intron sequences from nascent mRNAs. Recent work has suggested that the activity and composition of the spliceosome are regulated by ubiquitination, but the underlying mechanisms have not been elucidated. Here, we re...

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Détails bibliographiques
Auteurs principaux: Song, Eun Joo, Werner, Shannon L., Neubauer, Jakob, Stegmeier, Frank, Aspden, Julie, Rio, Donald, Harper, J. Wade, Elledge, Stephen J., Kirschner, Marc W., Rape, Michael
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2010
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895201/
https://ncbi.nlm.nih.gov/pubmed/20595234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1925010
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