Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and facilitate fat storage....

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Detalhes bibliográficos
Main Authors: Walker, Amy K., Yang, Fajun, Jiang, Karen, Ji, Jun-Yuan, Watts, Jennifer L., Purushotham, Aparna, Boss, Olivier, Hirsch, Michael L., Ribich, Scott, Smith, Jesse J., Israelian, Kristine, Westphal, Christoph H., Rodgers, Joseph T., Shioda, Toshi, Elson, Sarah L., Mulligan, Peter, Najafi-Shoushtari, Hani, Black, Josh C., Thakur, Jitendra K., Kadyk, Lisa C., Whetstine, Johnathan R., Mostoslavsky, Raul, Puigserver, Pere, Li, Xiaoling, Dyson, Nicholas J., Hart, Anne C., Näär, Anders M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895199/
https://ncbi.nlm.nih.gov/pubmed/20595232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1901210
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