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Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

Failure of remyelination is largely responsible for sustained neurologic symptoms in multiple sclerosis (MS). MS lesions contain hyaluronan deposits that inhibit oligodendrocyte precursor cell (OPC) maturation. However, the mechanism behind this inhibition is unclear. We report here that Toll-like r...

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書誌詳細
主要な著者: Sloane, J. A., Batt, C., Ma, Y., Harris, Z. M., Trapp, B., Vartanian, T.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895128/
https://ncbi.nlm.nih.gov/pubmed/20534434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006496107
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