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Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2
Failure of remyelination is largely responsible for sustained neurologic symptoms in multiple sclerosis (MS). MS lesions contain hyaluronan deposits that inhibit oligodendrocyte precursor cell (OPC) maturation. However, the mechanism behind this inhibition is unclear. We report here that Toll-like r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895128/ https://ncbi.nlm.nih.gov/pubmed/20534434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006496107 |
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