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Lyn Kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor Pazopanib

We have recently shown that the gene encoding the truncated form of protein tyrosine phosphatase receptor-type O (PTPROt) expressed predominantly in hematopoietic cells, is epigenetically silenced in human primary chronic lymphocytic leukemia (B-CLL). To determine whether increased phosphorylation o...

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Autors principals: Motiwala, Tasneem, Datta, Jharna, Kutay, Huban, Roy, Satavisha, Jacob, Samson T.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895018/
https://ncbi.nlm.nih.gov/pubmed/20564182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22593
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