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Role of Astrocytes and Chemokine Systems in Acute TNFα induced Demyelinating Syndrome: CCR2-dependent Signals promote Astrocyte Activation and Survival via NF-κB and Akt

Chemotactic factors known as chemokines play an important role in the pathogenesis of Multiple Sclerosis (MS). Transgenic expression of TNFα in the central nervous system (CNS) leads to the development of a demyelinating phenotype (TNFα-induced demyelination; TID) that is highly reminiscent of MS. L...

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Bibliografiske detaljer
Main Authors: Quinones, Marlon P., Kalkonde, Yogeshwar, Estrada, Carlos A., Jimenez, Fabio, Ramirez, Robert, Mahimainathan, Lenin, Mummidi, Srinivas, Choudhury, Goutam G., Martinez, Hernan, Adams, Lisa, Mack, Matthias, Reddick, Robert L., Maffi, Shivani, Haralambous, Sylva, Probert, Lesley, Ahuja, Sunil K., Ahuja, Seema S.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894699/
https://ncbi.nlm.nih.gov/pubmed/17949991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2007.08.017
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