Role of Astrocytes and Chemokine Systems in Acute TNFα induced Demyelinating Syndrome: CCR2-dependent Signals promote Astrocyte Activation and Survival via NF-κB and Akt

Chemotactic factors known as chemokines play an important role in the pathogenesis of Multiple Sclerosis (MS). Transgenic expression of TNFα in the central nervous system (CNS) leads to the development of a demyelinating phenotype (TNFα-induced demyelination; TID) that is highly reminiscent of MS. L...

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Hauptverfasser: Quinones, Marlon P., Kalkonde, Yogeshwar, Estrada, Carlos A., Jimenez, Fabio, Ramirez, Robert, Mahimainathan, Lenin, Mummidi, Srinivas, Choudhury, Goutam G., Martinez, Hernan, Adams, Lisa, Mack, Matthias, Reddick, Robert L., Maffi, Shivani, Haralambous, Sylva, Probert, Lesley, Ahuja, Sunil K., Ahuja, Seema S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894699/
https://ncbi.nlm.nih.gov/pubmed/17949991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2007.08.017
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