CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation

Ligands of CCR5, the major coreceptor of HIV-1, costimulate T lymphocyte activation. However, the full impact of CCR5 expression on T cell responses remains unknown. Here, we show that compared with CCR5(+/+), T cells from CCR5(−/−) mice secrete lower amounts of IL-2, and a similar phenotype is obse...

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Autori principali: Camargo, Jose F., Quinones, Marlon P., Mummidi, Srinivas, Srinivas, Sowmya, Gaitan, Alvaro A., Begum, Kazi, Jimenez, Fabio, VanCompernolle, Scott, Unutmaz, Derya, Ahuja, Seema S., Ahuja, Sunil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937277/
https://ncbi.nlm.nih.gov/pubmed/19109148
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