Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells

CC chemokine receptor 5 (CCR5) is the major HIV-1 coreceptor and its expression levels are a critical determinant of HIV-1 infection. However, the molecular mechanisms of CCR5 regulation in primary targets of HIV-1 remain unknown. Despite binding to conserved DNA elements, we show that the transcrip...

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Detalhes bibliográficos
Main Authors: Sundrud, Mark S., VanCompernolle, Scott E., Eger, Karla A., Bruno, Tullia C., Subramaniam, Arun, Mummidi, Srinivas, Ahuja, Sunil K., Unutmaz, Derya
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895046/
https://ncbi.nlm.nih.gov/pubmed/16091457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-0857
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