14-3-3 binding sites in the Snail protein are essential for Snail-mediated transcriptional repression and epithelial-mesenchymal differentiation

The Snail transcription factor is a repressor and a master regulator of epithelial-mesenchymal transition events (EMT) in normal embryonic development and during tumor metastases. Snail directly regulates genes affecting cell adhesion, motility and polarity. Invasive tumor cells express high levels...

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Hlavní autoři: Hou, Zhaoyuan, Peng, Hongzhuang, White, David E., Wang, Pu, Lieberman, Paul M., Halazonetis, Thanos, Rauscher, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894621/
https://ncbi.nlm.nih.gov/pubmed/20501852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0070
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