Differential Role of Snail1 and Snail2 Zinc Fingers in E-cadherin Repression and Epithelial to Mesenchymal Transition

Snail1 (Snail) and Snail2 (Slug) are transcription factors that share a similar DNA binding structure of four and five C(2)H(2) zinc finger motifs (ZF), respectively. Both factors bind specifically to a subset of E-box motifs (E2-box: CAGGTG/CACCTG) in target promoters like the E-cadherin promoter a...

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Autores principales: Villarejo, Ana, Cortés-Cabrera, Álvaro, Molina-Ortíz, Patricia, Portillo, Francisco, Cano, Amparo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887216/
https://ncbi.nlm.nih.gov/pubmed/24297167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528026
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