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Probing Soluble Guanylate Cyclase Activation by CO and YC-1 using Resonance Raman Spectroscopy

Soluble guanylate cyclase (sGC) is weakly activated by CO but is significantly activated by the binding of YC-1 to the sGC-CO complex. In this report resonance Raman (RR) spectroscopy was used to study selected sGC variants. Addition of YC-1 to the sGC-CO complex alters the intensity pattern of RR b...

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Autors principals: Ibrahim, Mohammed, Derbyshire, Emily R., Marletta, Michael A., Spiro, Thomas G.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894327/
https://ncbi.nlm.nih.gov/pubmed/20353168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902214j
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