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Hyperleptinemia Is Required for the Development of Leptin Resistance

Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance. The physiological causes of leptin resistance remain poorly understood. Here we t...

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Bibliografische gegevens
Hoofdauteurs: Knight, Zachary A., Hannan, K. Schot, Greenberg, Matthew L., Friedman, Jeffrey M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894068/
https://ncbi.nlm.nih.gov/pubmed/20613882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011376
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