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Hyperleptinemia Is Required for the Development of Leptin Resistance

Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance. The physiological causes of leptin resistance remain poorly understood. Here we t...

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Autors principals: Knight, Zachary A., Hannan, K. Schot, Greenberg, Matthew L., Friedman, Jeffrey M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894068/
https://ncbi.nlm.nih.gov/pubmed/20613882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011376
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