Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body

Recycling of eIF2-GDP to the GTP-bound form constitutes a core essential, regulated step in eukaryotic translation. This reaction is mediated by eIF2B, a heteropentameric factor with important links to human disease. eIF2 in the GTP-bound form binds to methionyl initiator tRNA to form a ternary comp...

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Hlavní autoři: Taylor, Eleanor J., Campbell, Susan G., Griffiths, Christian D., Reid, Peter J., Slaven, John W., Harrison, Richard J., Sims, Paul F.G., Pavitt, Graham D., Delneri, Daniela, Ashe, Mark P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893985/
https://ncbi.nlm.nih.gov/pubmed/20444979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-11-0962
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