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Investigation of clinical interaction between omeprazole and tacrolimus in CYP3A5 non-expressors, renal transplant recipients

BACKGROUND: As proton pump inhibitors share CYP3A4 enzyme with tacrolimus for their hepatic elimination, they potentially affect its pharmacokinetics, most prominently in patients with CYP2C19 or CYP3A5 gene mutations. Our aim was to investigate the impact of omeprazole on tacrolimus pharmacokinetic...

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Main Authors: Katsakiori, Paraskevi F, Papapetrou, Eirini P, Goumenos, Dimitrios S, Nikiforidis, George C, Flordellis, Christodoulos S
פורמט: Artigo
שפה:Inglês
יצא לאור: Dove Medical Press 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893758/
https://ncbi.nlm.nih.gov/pubmed/20596503
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