CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis

Deficiency in Cathepsin D (CtsD), the major cellular lysosomal aspartic proteinase, causes the congenital form of neuronal ceroid lipofuscinoses (NCLs). CtsD-deficient mice show severe visceral lesions like lymphopenia in addition to their central nervous system (CNS) phenotype of ceroid accumulatio...

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Detalhes bibliográficos
Main Authors: Shevtsova, Zinayida, Garrido, Manuel, Weishaupt, Jochen, Saftig, Paul, Bähr, Mathias, Lühder, Fred, Kügler, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893670/
https://ncbi.nlm.nih.gov/pubmed/20489146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091267
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