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Morphological and Functional Correlates of Synaptic Pathology in the Cathepsin D Knock-Out Mouse Model of Congenital Neuronal Ceroid-Lipofuscinosis
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early even...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242052/ https://ncbi.nlm.nih.gov/pubmed/22082660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318238fc28 |
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