N-Acetylcysteine and 15 Deoxy-(Δ12,14)-Prostaglandin J2 Exert a Protective Effect Against Autoimmune Thyroid Destruction in Vivo but Not Against Interleukin-1α/Interferon γ-Induced Inhibitory Effects in Thyrocytes in Vitro

Reactive oxygen species (ROS) are crucial for thyroid hormonogenesis, and their production is kept under tight control. Oxidative stress (OS) is toxic for thyrocytes in an inflammatory context. In vitro, Th1 pro-inflammatory cytokines have already been shown to decrease thyroid-specific protein expr...

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Detalhes bibliográficos
Main Authors: Poncin, Sylvie, Colin, Ides M., Decallonne, Brigitte, Clinckspooor, Isabelle, Many, Marie-Christine, Denef, Jean-François, Gérard, Anne-Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893665/
https://ncbi.nlm.nih.gov/pubmed/20489149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091253
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