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The Aminolysis Reaction of Streptomyces S9 Aminopeptidase Promotes the Synthesis of Diverse Prolyl Dipeptides

Prolyl dipeptide synthesis by S9 aminopeptidase from Streptomyces thermocyaneoviolaceus (S9AP-St) has been demonstrated. In the synthesis, S9AP-St preferentially used l-Pro-OBzl as the acyl donor, yielding synthesized dipeptides having an l-Pro-Xaa structure. In addition, S9AP-St showed broad specif...

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Main Authors: Arima, Jiro, Morimoto, Masazumi, Usuki, Hirokazu, Mori, Nobuhiro, Hatanaka, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893465/
https://ncbi.nlm.nih.gov/pubmed/20418423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00577-10
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