A Phase I Study of Bortezomib in Combination With Standard 5-Fluorouracil and External-Beam Radiation Therapy for the Treatment of Locally Advanced or Metastatic Rectal Cancer

BACKGROUND: Standard therapy for stage II/III rectal cancer consists of a fluoropyrimidine and radiation therapy followed by surgery. Preclinical data demonstrated that bortezomib functions as a radiosensitizer in colorectal cancer models. The purpose of this study was to determine the maximum toler...

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書誌詳細
主要な著者: O’Neil, Bert H., Raftery, Laura, Calvo, Benjamin F., Chakravarthy, A. Bapsi, Ivanova, Anastasia, Myers, Michael O., Kim, Hong Jin, Chan, Emily, Wise, Paul E., Caskey, Laura S., Bernard, Stephen A., Sanoff, Hanna K., Goldberg, Richard M., Tepper, Joel E.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893386/
https://ncbi.nlm.nih.gov/pubmed/20378507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3816/CCC.2010.n.017
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