Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

BACKGROUND: Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I is the notorious point mutation that causes resistance to imatinib and the second generation tyrosine kinase inhibitors, leading to poor prognosis. CML blasts have constitutive p65...

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Detalhes bibliográficos
Main Authors: Lu, Zhongzheng, Jin, Yanli, Chen, Chun, Li, Juan, Cao, Qi, Pan, Jingxuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893099/
https://ncbi.nlm.nih.gov/pubmed/20482842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-112
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