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Endothelial lumen signaling complexes control 3D matrix–specific tubulogenesis through interdependent Cdc42- and MT1-MMP–mediated events
Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)–B and Jam-C, membrane type 1–matrix metalloproteinase (MT1-MMP), and integrin α(2)β(1), which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockad...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892954/ https://ncbi.nlm.nih.gov/pubmed/20215637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-252692 |
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