Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP–dependent proteolysis in 3-dimensional collagen matrices

Here we show that endothelial cells (EC) require matrix type 1-metalloproteinase (MT1-MMP) for the formation of lumens and tube networks in 3-dimensional (3D) collagen matrices. A fundamental consequence of EC lumen formation is the generation of vascular guidance tunnels within collagen matrices th...

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Detalhes bibliográficos
Main Authors: Stratman, Amber N., Saunders, W. Brian, Sacharidou, Anastasia, Koh, Wonshill, Fisher, Kevin E., Zawieja, David C., Davis, Michael J., Davis, George E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714200/
https://ncbi.nlm.nih.gov/pubmed/19339693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-196451
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