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Formation of endothelial lumens requires a coordinated PKCε-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation

In this study, we present data showing that Cdc42-dependent lumen formation by endothelial cells (ECs) in three-dimensional (3D) collagen matrices involves coordinated signaling by PKCε in conjunction with the Src-family kinases (SFKs) Src and Yes. Activated SFKs interact with Cdc42 in multiprotein...

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Autors principals: Koh, Wonshill, Sachidanandam, Kamakshi, Stratman, Amber N., Sacharidou, Anastasia, Mayo, Anne M., Murphy, Eric A., Cheresh, David A., Davis, George E.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684834/
https://ncbi.nlm.nih.gov/pubmed/19435802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.045799
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