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Selective molecular potassium channel blockade prevents atrial fibrillation

BACKGROUND: Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that atrial gene transfer would allow focal manipulation of atrial electrophysiology, and by eliminating reentry, would prevent AF. METHODS AND RESULTS: In a porcine AF model, we compared co...

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Autors principals: Guy, Amit, Kikuchi, Kan, Greener, Ian D., Yang, Lizhu, Novack, Victor, Donahue, J. Kevin
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892844/
https://ncbi.nlm.nih.gov/pubmed/20479154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.911156
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