Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

The heparan sulfate (HS) proteoglycan perlecan is a major component of basement membranes, plays a key role in extracellular matrix (ECM) structure, interacts with growth factors and adhesion molecules, and regulates the adhesion, differentiation and proliferation of vascular cells. Atherosclerosis...

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Detalhes bibliográficos
Main Authors: Kennett, Eleanor C., Rees, Martin D., Malle, Ernst, Hammer, Astrid, Whitelock, John M., Davies, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2010
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892749/
https://ncbi.nlm.nih.gov/pubmed/20416372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.04.018
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