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IL-1R signaling within the CNS regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by disruption of the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred trafficking of myelin-specific lymphocytes into the CNS where they induce demyelination. Although t...

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Detalhes bibliográficos
Main Authors: McCandless, Erin E., Budde, Matthew, Lees, Jason R., Dorsey, Denise, Lyng, Eric, Klein, Robyn S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892701/
https://ncbi.nlm.nih.gov/pubmed/19535637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802258
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