Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

Multiple sclerosis (MS) is an inflammatory disease of the CNS that is characterized by BBB dysfunction and has a much higher incidence in females. Compared with other strains of mice, EAE in the SJL mouse strain models multiple features of MS, including an enhanced sensitivity of female mice to dise...

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Detalhes bibliográficos
Main Authors: Cruz-Orengo, Lillian, Daniels, Brian P., Dorsey, Denise, Basak, Sarah Alison, Grajales-Reyes, José G., McCandless, Erin E., Piccio, Laura, Schmidt, Robert E., Cross, Anne H., Crosby, Seth D., Klein, Robyn S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089451/
https://ncbi.nlm.nih.gov/pubmed/24812668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73408
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