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Phase I Trial of 2-Methoxyestradiol (2ME2, Panzem(®)) NanoCrystal(®) Dispersion (NCD(®)) in Advanced Solid Malignancies
PURPOSE: 2-methoxyestradiol (2ME2, Panzem(®)) is an endogenous, estradiol-17β metabolite which at pharmacological doses exerts antimitotic and antiangiogenic activities. Studies with a 2ME2 capsule formulation showed limited oral bioavailability. We report the results of a phase I study using a Nano...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892631/ https://ncbi.nlm.nih.gov/pubmed/19228747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1599 |
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