Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma

Anthrax is caused by strains of Bacillus anthracis that produce two key virulence factors, anthrax toxin (Atx) and a poly-γ-D-glutamic acid capsule. Atx is comprised of three-proteins: protective antigen (PA) and two enzymes, lethal factor (LF) and edema factor (EF). To disrupt cell function, these...

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Main Authors: Kintzer, Alexander F., Sterling, Harry J., Tang, Iok I., Abdul-Gader, Ali, Miles, Andrew J., Wallace, B. A., Williams, Evan R., Krantz, Bryan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892534/
https://ncbi.nlm.nih.gov/pubmed/20433851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.041
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