Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

BACKGROUND: In preparation for potential clinical development of Ab-01, an antagonistic antibody directed against the IL21R, studies were undertaken to address translational medicine needs that fall into four categories: 1) development of a pharmacodynamic biomarker assay suitable for use in the cli...

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Autori principali: Arai, Maya, Jain, Sadhana, Weaver, Amy A, Hill, Andrew A, Guo, Yongjing, Bree, Andrea G, Smith, Michael F, Allen, Scott W, LaVallie, Edward R, Young, Deborah, Bloom, Laird, Adkins, Karissa, O'Toole, Margot
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892437/
https://ncbi.nlm.nih.gov/pubmed/20509950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-51
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