Development of Antiproliferative Phenylmaleimides that Activate the Unfolded Protein Response

The current paper presents the synthesis and evaluation of a series of maleimides that were designed to inhibit the Cdc25 phosphatase by alkylation of catalytically essential cysteine residues. Although in HepB3 cell culture assays the analogues did exhibit antiproliferative IC(50) values ranging fr...

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Autores principales: Muus, Ulrike, Hose, Curtis, Yao, Wei, Kosakowska-Cholody, Teresa, Farnsworth, David, Dyba, Marzena, Lountos, George T., Waugh, David S., Monks, Anne, Burke, Terrence R., Michejda, Christopher J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892248/
https://ncbi.nlm.nih.gov/pubmed/20472436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.04.057
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