Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein

AIMS/HYPOTHESIS: Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in the development of intimal hyperplasia in saphenous vein (SV) bypass grafts. In diabetic patients, insulin administration controls hyperglycaemia but cardiovascular complications remain. Insulin is synthesised...

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Main Authors: Mughal, R. S., Scragg, J. L., Lister, P., Warburton, P., Riches, K., O’Regan, D. J., Ball, S. G., Turner, N. A., Porter, K. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892072/
https://ncbi.nlm.nih.gov/pubmed/20461358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1736-6
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