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The Enteropathogenic E. coli Effector EspF Targets and Disrupts the Nucleolus by a Process Regulated by Mitochondrial Dysfunction

The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus—a feature exclusive to this pathogen group. Here, using a combination of bio-imaging, genetic and biochemical analys...

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Detalhes bibliográficos
Main Authors: Dean, Paul, Scott, Jon A., Knox, Andrew A., Quitard, Sabine, Watkins, Nicholas J., Kenny, Brendan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891835/
https://ncbi.nlm.nih.gov/pubmed/20585567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000961
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