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Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ(3)

During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development. Intervillous blood flow increases around 10 to 12 weeks of gestation and results in exposure of trophoblast cells to increased oxygen tension. Before this time, lo...

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Udgivet i:J Clin Invest
Principais autores: Caniggia, Isabella, Mostachfi, Homa, Winter, Jennifer, Gassmann, Max, Lye, Stephen J., Kuliszewski, Maciej, Post, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289179/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712429/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8316
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